Recainam (Wy-42362) is an orally active anti-arrthmic agent with Class I electropsiological properties. Recainam suppresses complex ventricular arrthmias. Racainam exhibits a good pharmacokinetic character in Sprague Dawley rats.
Racainam (20 mg/kg, i.v.) exhibits a good pharmacokinetic profil with an AUC0-inf of 4.1 μg·h/mL, a half-time T1/2 of 0.6 h, MRT of 0.6 h, a clearance of 4.9 L/kg·h and a distribution Vss of 3.2 L/kg[1].
References:
[1]. Scatina JA, et al., Species differences in the pharmacokinetics of recainam, a new anti-arrthmic drug. Biopharm Drug Dispos. 1990 Jul;11(5):445-61.
[2]. Anastasiou-Nana MI, et al., Recainam, a potent new antiarrthmic agent: effects on complex ventricular arrthmias. J Am Coll Cardiol. 1986 Aug;8(2):427-35.