RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase[1].
RDR 02308 (0-10 μM; 1 h) 在 RAW264.7 细胞中抑制 LPS 介导的 IL-6 产生[1]。
Western Blot Analysis[1]
| Cell Line: | RAW264.7 cells |
| Concentration: | 0-10 μM |
| Incubation Time: | 1 h |
| Result: | Inhibited LPS-mediated IL-6 production. |
[1]. Lee HK, et al. Application of beta-lactamase enzyme complementation to the high-throughput screening of toll-like receptor signaling inhibitors. Mol Pharmacol. 2007 Oct;72(4):868-75.