| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 5mg | ¥1,350.00 | 现货 | 1 | |
| 10mg | ¥2,025.00 | 现货 | 1 | |
| 25mg | ¥3,870.00 | 现货 | 1 | |
| 50mg | ¥6,165.00 | 现货 | 1 | |
| 100mg | ¥11,656.00 | 现货 | 1 | |
| 10mM (in 1mL DMSO) | ¥1,485.00 | 现货 | 1 |
RCM-1 is a nontoxic inhibitor of Forkhead box M1 (FOXM1) that suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. RCM-1 decreases carcinogenesis and nuclear β-catenin.
[1] Lifeng Sun, et al. Sci Signal. 2017 Apr 18;10(475):eaai8583. [2] Samriddhi Shukla, et al. Mol Cancer Ther. 2019 Jul;18(7):1217-1229.
Cell experiment: | Rd76-9 rhabdomyosarcoma, B16-FlO melanoma, H2122 lung adenocarcinoma, 4T1 breast carcinoma, MyC-CaP prostate carcinoma and KPC-2 pancreatic carcinoma cells are seeded in 6-well plates and incubated overnight. The cells are treated with 20 μM concentration of RCM-1 for 24, 48 and 72 h and cell growth is analyzed by counting alive cells using trypan blue. Cells treated with DMSO are used as controls[1]. |
Animal experiment: | Mice[1]Mouse Rd76-9 rhabdomyosarcoma cells (1×106 cells) are injected intramuscularly in the flanks of C56Bl/6J mice (n=8 mice per group). Seven days after the tumor cells inoculation, 40 μL of either Vehicle (DMSO) or RCM-1 (20 mg/kg body weight) are injected intraperitoneally in the animals every other day. The animals are sacrificed and tumors are harvested on day 16. RCM-1 treatment decreases Rd76-9 tumor growth as compared to the DMSO-treated group. Mouse B 16-FlO melanoma cells (1×106 cells) are injected subcutaneously in C56Bl/6J mice (n=7 animals per group). Three days after the tumor cell inoculation, 40 μL of either Vehicle (DMSO) or RCM1 (20 mg/Kg body weight) are injected intraperitoneally in the animals every other day. The animals are sacrificed and tumors are harvested on day 12[1]. |
References: [1]. ARYL SULFONOHYDRAZIDES.WO2018057550A1. |
