Rafoxanide is an anthelmintic.1,2,3 In vivo, rafoxanide (50 mg/kg) completely eradicates E. caproni infection in mice.1 It is active against H. contortus in sheep when administered at a dose of 10 mg/kg and eliminates mature F. hepatica flukes in cattle when administered at a dose of 7.5 mg/kg.2,3 It is also cytotoxic to A375 and A431 skin cancer cells in vitro (IC50s = 10.9 and 1.31 ?M, respectively) and reduces tumor growth in an A375 mouse xenograft model when administered at a dose of 40 mg/kg.3 Formulations containing rafoxanide have been used in the treatment of parasitic infections in sheep and cattle.
1.K., M., Decere, M., and Fried, B.Effects of the anthelmintics clorsulon, rafoxanide, mebendazole and arprinocid on Echinostoma caproni in ICR miceJ. Helminthol.70(1)95-96(1996) 2.Egerton, J.R., Yakstis, J.J., and Campbell, W.C.Efficacy of rafoxanide (3,5-diiodo-3'-chloro-4'-(p-chlorophenoxy) salicylanilide) against Haemonchus contortus in sheepRes. Vet. Sci.11(4)382-388(1970) 3.Knapp, S.E., and Presidente, P.J.A.Efficacy of rafoxanide against natural fasciola hepatica infections in cattleAm. J. Vet. Res.32(8)1289-1291(1971)