(Rac)-SHIN2 is a serine droxymetltransferase (SHMT) inhibitor having 1,4-didropyrano[2,3-c]pyrazole structure. (Rac)-SHIN2 involves in folate or one-carbon metabolism pathways, prevents viral infection. SHMT1 and SHMT2 are the cytosolic and/or mitochondrial isoforms of serine droxymetltransferase, respectively[1].
[1]. Mootha Vamsi, et al. Method of treating and preventing viral infection comprising inhibitors of folate or one-carbon metabolism pathways such as serine droxymetltransferase inhibitors: World Intellectual Property Organization, WO2022120195[P]. 2022-06-09.