GlpBio

(R,S,R)-ML334

目录号: GC72820纯度: >98.00%同义词: (R,S,R)-LH601A
(R,S,R)-ML334是ML334的异构体并且可以用作实验对照。
(R,S,R)-ML334
Cas No.: 1432065-33-2
规格价格库存数量操作
1 mg¥387.00现货
1
5 mg¥855.00现货
1
10 mg¥1,350.00现货
1
25 mg¥2,700.00现货
1
50 mg¥4,320.00现货
1
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文献被引

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产品描述 Description

(R,S,R)-ML334 is the isomer of ML334 , and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity.

References:
[1]. Wen X, et al. Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor. J Biochem Mol Toxicol. 2015 Jun;29(6):261-6.
[2]. Hu L, et al. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem Lett. 2013 May 15;23(10):3039-43.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
1432065-33-2
同义词
(R,S,R)-LH601A
分子式
C26H26N2O5
分子量
446.5 g/mol
溶解性
DMSO : 100 mg/mL (223.96 mM; Need ultrasonic)
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol