(R)-γ-Valerolactone is a five-membered-ring lactone, which can be used as a precursor for more valuable biopharmaceuticals and bioplastics than biofuels[1-2]. (R)-γ-Valerolactone can be derived from algal biomass and CO2, and exhibits a perfect enantiomeric excess of over 99.99%[2-3]. (R)-γ-valerolactone can be used for the synthesis of Cladospolide-C and (+)-Patulolide-C[4-5].
References:
[1] Quang Anh Tuan Le, Seonghoon Kim, et al. Insights into the Lactonase Mechanism of Serum Paraoxonase 1 (PON1): Experimental and Quantum Mechanics/Molecular Mechanics (QM/MM) Studies. The Journal of Physical Chemistry B. 2015; 119(30): 9461-9994.
[2] Cha, J., et al. Algal biomass-based zero-waste biorefinery for producing optically pure (R)-γ-valerolactone and carbonaceous electrodes applicable for energy storage devices. Chemical Engineering Journal. 2024: 490 151731.
[3] Jaehyun Cha, Youngjun Choi, et al. Bio-mitigation of CO2: The co-production of phycocyanin and optically pure (R)-γ-valerolactone with perfect enantiomeric excess. Bioresource Technology. 2025; 418: 131895.
[4] Rajender Datrika, Srinivasa Reddy Kallam, et al. Formal synthesis of Cladospolide C & epi-Cladospolide C using R-(+)-γ-valerolactone as a chiral synthon. Tetrahedron. 2019; 75(19): 2824-2831.
[5] Rajender Datrika, Srinivasa Reddy Kallam, et al. Synthesis of (+)-Patulolide C Using R-(+)-γ-Valerolactone as a Chiral Synthon. ChemistrySelect. 2017; 2(21): 5828-5831.
(R)-γ-Valerolactone是一种五元环内酯，可用作生物制药和生物塑料的前体，价值高于生物燃料[1-2]。(R)-γ-Valerolactone可以通过藻类生物质和二氧化碳合成，并且具有超过99.99%的完美对映体 [2-3]。(R)-γ-Valerolactone可用于实现Cladospolide-C和 (+)-Patulolide-C的合成[4-5]。