Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside is a flavonol glycoside derivative and an acylated glycoside of quercetin[1]. Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside has excellent antioxidant activity in a cell-free environment, but does not exert the same protective effect in biological systems[2, 3]. Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside is mainly found in leguminous plants (such as soybeans and alfalfa) and some medicinal plants[4].
References:
[1] Petrova N V, Chernonosov A A, Koval V V, et al. LC–HRMS for the identification of quercetin and its derivatives in Spiraea hypericifolia (Rosaceae) and anatomical features of its leaves[J]. Plants, 2023, 12(2): 381.
[2] Panat N A, Amrute B K, Bhattu S, et al. Antioxidant Profiling of C3 Quercetin Glycosides: Quercitrin, Quercetin 3-β-D-glucoside and Quercetin 3-O-(6”-O-malonyl)-β-Dglucoside in cell free environment[J]. Free Radicals and Antioxidants, 2015, 5(2): 90-100.
[3] Alizadeh S R, Ebrahimzadeh M A. O‐Glycoside quercetin derivatives: Biological activities, mechanisms of action, and structure–activity relationship for drug design, a review[J]. Phytotherapy Research, 2022, 36(2): 778-807.
[4] Zhang Q, Zhao X, Qiu H. Flavones and flavonols: Phytochemistry and biochemistry[M]//Natural products. Springer, Berlin, Heidelberg, 2013: 1821-1847.
Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside是一种黄酮醇糖苷衍生物，属于槲皮素（Quercetin）的酰化糖苷[1]。Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside在无细胞环境中具有优异的抗氧化活性，但在生物系统中未发挥同等的保护作用[2, 3]。Quercetin 3-O-(6''-O-malonyl)-β-D-glucoside主要存在于豆科植物（如大豆、苜蓿）和部分药用植物中[4]。