QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival. (Pink: ligand for target protein Aberrant tau ligand 1 ; Black: linker NH2-PEG3 ; Blue: ligand for E3 ligase Pomalidomide )
References:
[1]. Silva MC, et al., Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 2019 Mar 25;8:e45457.