Pyrrolnitrin is pyrrole that has been found in B. cepacia and has diverse biological activities.1,2,3 It is active against isolates of the fungi C. albicans, C. neoformans, B. dermatitidis, S. schenckii, and H. capsulatum (MICs = <0.78-12.5 ?g/ml).1 Pyrrolnitrin is also active against a variety of Gram-positive bacteria, including S. antibioticus, B. subtilis, and S. aureus (MICs = 0.2, 6.25, and 12.5 ?g/ml, respectively).2 It reduces spore germination, germ-tube length, and sporulation in isolates of the phytopathogenic fungus B. cinerea (EC50s = 2.3-31.8 ?g/L).3 Pyrrolnitrin (50 mg/kg) reduces C. albicans levels by 74% in the kidney of infected mice.1
1.Gordee, R.S., and Matthews, T.R.Systemic antifungal activity of pyrrolnitrinAppl. Microbiol.17(5)690-694(1969) 2.El-Banna, N., and Winkelmann, G.Pyrrolnitrin from Burkholderia cepacia: Antibiotic activity against fungi and novel activities against streptomycetesJ. Appl. Microbiol.85(1)69-78(1998) 3.Ajouz, S., Walker, A.S., Fabre, F., et al.Variability of Botrytis cinerea sensitivity to pyrrolnitrin, an antibiotic produced by biological control agentsBioControl56(3)353-363(2011)