Pseudo-UTP,100mM Sodium Solution is a modified uridine triphosphate nucleotide commonly used in the research and development of mRNA vaccines and therapeutic mRNAs. By incorporating into mRNA molecules in place of natural uridine, Pseudo-UTP can reduce the immunogenicity of mRNA while enhancing its stability and translational efficiency[1-2].
References:
[1] Shanmugasundaram M, Senthilvelan A, Kore AR. Gram-Scale Chemical Synthesis of Base-Modified Ribonucleoside-5'-O-Triphosphates. Curr Protoc Nucleic Acid Chem. 2016 Dec 1;67:13.15.1-13.15.10.
[2] Tchigvintsev A, Tchigvintsev D, Flick R, et al. Biochemical and structural studies of conserved Maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides. Chem Biol. 2013 Nov 21;20(11):1386-98.
Pseudo-UTP,100mM Sodium Solution是一种修饰的尿苷三磷酸核苷酸，常用于mRNA疫苗和治疗性mRNA的研发。Pseudo-UTP通过掺入mRNA分子来替代天然尿苷，能够降低mRNA的免疫原性，并提高其稳定性和翻译效率[1-2]。