Protectin D1 methyl ester is an esterified form of the specialized pro-resolving mediator protectin D1 . It is an intermediate in the synthesis of protectin D1.1 Protectin D1 methyl ester (333 µg/kg) reduces infarct area and volume and increases blood vessel density in the tissue surrounding the infarct in a rat model of ischemic stroke induced by middle cerebral artery occlusion (MCAO).2
1.Rodriguez, A.R., and Spur, B.W.Total synthesis of the potent anti-inflammatory lipid mediator Protectin D1Tetrahedron Lett.55(43)6011-6015(2014) 2.Bazan, N.G., Eady, T.N., Khoutorova, L., et al.Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental strokeExp. Neurol.236(1)122-130(2012)