Prostaglandin F1α-d9

Prostaglandin F_1α-d₉ (PGF_1α.-d₉) contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of PGF_1α by GC- or LC-mass spectrometry. PGF_1α is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF_1α and PGF_2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10-11 M.¹ PGF_1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF_2α.² It is only half as active as PGF_2α in inducing human respiratory smooth muscle contractions in vitro.³

1.Moore, A., and Waring, C.P.Electrophysiological and endocrinological evidence that F-series prostaglandins function as priming pheromones in mature male Atlantic salmon (Salmo salar) PARRJ. Exp. Biol.199(Pt 10)2307-2316(1996) 2.Balapure, A.K., Rexroad, C.E., Jr., Kawada, K., et al.Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptorBiochem. Pharmacol.38(14)2375-2381(1989) 3.Karim, S.M.M., Adaikan, P.G., and Kottegoda, S.R.Prostaglandins and human respiratory tract smooth muscle: Structure activity relationshipAdvances in Prostaglandin and Thromboxane Research7969-980(1980)