Prosaptide TX14(A) is a peptide fragment of the neurotrophic factor prosaposin and an agonist of GPR37L1 and GPR37.1 It activates ERK signaling in HEK293T cells expressing GPR37L1 or GPR37 (EC50s = 5 and 7 nM, respectively) and inhibits forskolin-induced cAMP production in the same cells. Prosaptide TX14(A) (100 nM) protects primary mouse astrocytes from hydrogen peroxide-induced cell death. It reduces allodynia in a variety of rat peripheral pain models, including models of diabetic neuropathy and sciatic nerve hemiligation when administered at a dose of 4 mg/kg, as well as prevents paw allodynia induced by formalin at 1 mg/kg.2
1.Meyer, R.C., Giddens, M.M., Schaefer, S.A., et al.GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposinProc. Natl. Acad. Sci. USA110(23)9529-9534(2013) 2.Jolivalt, C.G., Ramos, K.M., Herbetsson, K., et al.Therapeutic efficacy of prosaposin-derived peptide on different models of allodyniaPain121(1-2)14-21(2006)