Propargyl-PEG3-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Thorsten Heidelberg, et al. Oligo-ethylene glycol based phosphonate surface modification reagents and use thereof. WO2015065168A1.
















