Promethazine-d3 is intended for use as an internal standard for the quantification of promethazine by GC- or LC-MS. Promethazine is categorized as a phenothiazine.[1] It has been associated with misuse in conjunction with opioids or sedatives.[1],[2] Formulations containing promethazine have been used in the treatment of various allergy-related conditions, anesthesia- or surgery-related nausea and vomiting, and to induce sedation. This product is intended for research and forensic applications.
References:
[1].Tsay, M.E., Procopio, G., Anderson, B.D., et al.Abuse and intentional misuse of promethazine reported to US Poison Centers: 2002 to 2012J. Addict. Med.9(3)233-237(2015).
[2].Chiappini, S., Schifano, F., Corkery, J.M., et al.Beyond the 'purple drank': Study of promethazine abuse according to the European Medicines Agency adverse drug reaction reportsJ. Psychopharmacol.35(6)681-692(2021).