Progesterone-d9 is intended for use as an internal standard for the quantification of progesterone by GC- or LC-MS. Progesterone is the biosynthetic precursor of all other steroid hormones.1 Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells. Progesterone activates the human progesterone receptor with an EC50 value of 0.5 nM.2
1.Erickson, G.F.The ovary: Basic principles and concepts. A. PhysiologyEndocrinology and Metabolism3rd ed.973-1015(1995) 2.Pedram, B., van Oeveren, A., Mais, D.E., et al.A tissue-selective nonsteroidal progesterone receptor modulator: 7,9-Difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4-f]quinolineJ. Med. Chem.51(13)3696-3699(2008)