Polysarcosine20 is an amine-functionalized hydrophilic polymer.1 Addition of polysarcosine20 to surface-grafted polymer brushes reduces protein absorption and mammalian and bacterial cell attachment, indicating potential use as an antifouling agent. Surface modification of liposomes with polysarcosine polymers between 10 and 100 units long have been used to increase circulation half-life.2,3
References:
[1]. Lau, K.H.A., Ren, C., Sileika, T.S., et al.Surface-grafted polysarcosine as a peptoid antifouling polymer brushLangmuir28(46)16099-16107(2012).
[2]. Weber, B., Seidl, C., Schwiertz, D., et al.Polysarcosine-based lipids: From lipopolypeptoid micelles to stealth-like lipids in Langmuir Blodgett monolayersPolymers (Basel)8(12)427(2016).
[3]. Bleher, S., Buck, J., Muhl, C., et al.Poly(sarcosine) surface modification imparts stealth-like properties to liposomesSmall15(50)e1904716(2019).