PNU-101603 is a sulfoxide metabolite of Sutezolid . PNU-101603 alone or combined with SQ109 shows excellent activity against Mycobacterium tuberculosis (MTB), as well as against drug-susceptible and multidrug-resistant TB[1][2].
PNU-101603 (compound 7, 21 days) inhibits M. tuberculosis activity[2].
Cell Viability Assay[2]
| Cell Line: | M. tuberculosis |
| Concentration: | 0-1 μg/mL approximately |
| Incubation Time: | 21 days |
| Result: | Inhibited M. tuberculosis with a MIC value ≤0.125 μg/mL. |
[1]. Reddy VM, et al. SQ109 and PNU-100480 interact to kill Mycobacterium tuberculosis in vitro. J Antimicrob Chemother. 2012 May;67(5):1163-6.
[2]. Barbachyn MR, et al. Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity. J Med Chem. 1996 Feb 2;39(3):680-5.