Picosulfate is a stimulant laxative and prodrug form of desacetyl bisacodyl .1 Unlike bisacodyl , picosulfate is hydrolyzed to DAB by colonic microbiota. Picosulfate (5 mg/kg) increases excreted fecal weight in a rat model of loperamide-induced constipation.2 Formulations containing picosulfate have been used for colonoscopy preparation.
1.Twycross, R., Sykes, N., Mihalyo, M., et al.Stimulant laxatives and opioid-induced constipationJ. Pain Symptom Manage.43(2)306-313(2012) 2.MÉitÉ, S., Bahi, C., YÉo, D., et al.Laxative activities of Mareya micrantha (Benth.) MÜll. Arg. (Euphorbiaceae) leaf aqueous extract in ratsBMC Complement. Altern. Med.107(2010)