Phytantriol is an aliphatic alcohol that has been used in the formation of liquid crystalline nanoparticles (LCNPs) and cubosomes.1,2 Cubosomes containing phytantriol are bactericidal against LPS-deficient and polymyxin-resistant A. baumannii strains.1 LCNPs containing phytantriol and encapsulating the isoquinoline alkaloid berberine reduce TNF-α and inducible nitric oxide synthase (iNOS) levels and the production of reactive oxygen species (ROS) in LPS-activated RAW 264.7 macrophages.2
References:
[1]. Lai, X., Ding, Y., Wu, C.M., et al.Phytantriol-based cubosome formulation as an antimicrobial against lipopolysaccharide-deficient Gram-negative bacteriaACS Appl. Mater. Interfaces12(40)44485-44498(2020).
[2]. Alnuqaydan, A.M., Almutary, A.G., Azam, M., et al.Phytantriol-based berberine-loaded liquid crystalline nanoparticles attenuate inflammation and oxidative stress in lipopolysaccharide-induced RAW26.
[4]. 7 macrophagesNanomaterials (Basel)12(23)4312(2022).