Phorbol is a diterpene originally isolated from croton oil.1 It is used as a starting material for the semisynthesis of various phorbol diesters, which are structurally analogous to diacylglycerol and activate PKC isoforms by associating with their C1 domains.2
1.Bohm, R., Flaschentrager, B., and Lendle, L.The activity of substances from croton oilArchiv fuer Experimentelle Pathologie und Pharmakologie177212-220(1935) 2.Hurley, J.H., Newton, A.C., Parker, P.J., et al.Taxonomy and function of C1 protein kinase C homology domainsProtein Sci.6(2)477-480(1997)
















