GlpBio

Peptide YY (3-36) (trifluoroacetate salt)

目录号: GC52502纯度: >95.00%同义词: Pancreatic Peptide YY, Peptide Tyrosine Tyrosine
A satiety hormone
Peptide YY (3-36) (trifluoroacetate salt)
规格价格库存数量操作
1 mg¥5,236.00现货
1
500 μg¥2,758.00现货
1
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产品描述 Description

Peptide YY (PYY) is a polypeptide that is released postprandially in proportion to meal energy content by endocrine L cells in the ileum and colon in order to regulate appetite.1 PYY, along with neuropeptide Y , inhibits gastrointestinal motility and electrolyte secretion, which is thought to indicate satiety through a potent feedback signal on hypothalamic circuits.1,2 Upon release, PYY is cleaved to PYY (3-36), which is a preferred agonist at presynaptic inhibitory type 2 NPY autoreceptors (EC50 = 11.4 nM in human colon mucosa).3 PYY (3-36) has been associated with dose-dependent weight loss in various obesity models including ob/ob mice, diet-induced obese mice, and non-diabetic fatty Zucker rats.2

1.Holzer, P., Reichmann, F., and Farzi, A.Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axisNeuropeptides46(6)261-274(2012) 2.le Roux, C.W., and Bloom, S.R.Peptide YY, appetite and food intakeProc. Nutr. Soc.64(2)213-216(2005) 3.Cox, H.M., and Tough, I.R.Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosaBr. J. Pharmacol.135(6)1505-1512(2002)

产品文档 Product Documents

Purity:>95.00%Appearance:A lyophilized powder

化学性质Chemical Properties

同义词
Pancreatic Peptide YY, Peptide Tyrosine Tyrosine
SMILES
NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@]([C@@H](C)O)([H])NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@@H]1CCCN1C([C@H](CO)NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)NC(CNC([C@@H]2CCCN2C([C@@H](NC([C@H](CCC(O)=O)NC([C@@H]3CCCN3C([C@H](CCCCN)NC([C@@]([C@H](CC)C)([H])N[H])=O)=O)=O)=O)C)=O)=O)=O)=O)CC(O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CC=C(O)C=C4)=O)CC5=CC=C(O)C=C5)=O)C)=O)=O)=O)=O)CC6=CN=CN6)=O)CC7=CC=C(O)C=C7)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC8=CC=C(O)C=C8)=O.OC(C(F)(F)F)=O
分子式
C180H279N53O54 ? XCF3COOH
分子量
4049.5 g/mol
溶解性
DMSO: soluble,Water: 1 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol