Pepinemab (VX 15/2503) is a human monoclonal antibody against SEMA4D, a signalling protein 4D (SEMA4D), also known as CD100, which is a regulator of neuronal development and plays a role in a variety of cellular processes. Pepinemab can be used in the study of various neurodegenerative diseases such as Alzheimer's disease by blocking the activity of SEMA4D[1].
Pepinemab(VX 15/2503)(48 h) 显著抑制原代人类星形细胞 CC-2565 中葡萄糖转运蛋白 (GLUT-1) 和单羧酸转运蛋白 (MCT)4 的表达，并抑制 SEMA4D 引起的星形细胞葡萄糖摄取的减少[1]。
[1]. Elizabeth E Evans, et al. Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity. J Neuroinflammation. 2022 Aug 6;19(1):200.