Pentanoyl-coenzyme A (pentanoyl-CoA) is a derivative of CoA that contains the short-chain saturated fatty acid pentanoic acid and a metabolite of 3-oxovalproyl-CoA.[1] It is formed from 3-oxovalproyl-CoA by mitochondrial thiolases. Hepatic levels of pentanoyl-CoA and propionyl-CoA are increased in an Apc+/Min-FCCC mouse model of spontaneous colorectal cancer fed a low- or high-fat diet.[2]
References:
[1].Silva, M.F., Ruiter, J.P., Overmars, H., et al.Complete β-oxidation of valproate: Cleavage of 3-oxovalproyl-CoA by a mitochondrial 3-oxoacyl-CoA thiolaseBiochem. J.362(Pt 3)755-760(2002).
[2].Dazard, J.-E., Sandlers, Y., Doerner, S.K., et al.Metabolomics of ApcMin/+ mice genetically susceptible to intestinal cancerBMC Syst. Biol.8:72(2014).