Pendimethalin is a dinitroaniline herbicide.1 It controls johnsongrass and increases seed cotton yield when used at concentrations ranging from 0.56 to 1.12 kg/ha. Pendimethalin (25-500 ?M) induces the production of reactive oxygen species (ROS) and genotoxicity in isolated human peripheral lymphocytes.2 In vivo, pendimethalin (62.5, 125, and 250 mg/kg) increases renal and hepatic protein carbonylation, lipid peroxidation, necrosis, leukocyte infiltration, and formation of pyknotic nuclei in rats.3 Formulations containing pendimethalin have been used in the control of annual grasses in agriculture.
1.Jordan, T.N., Baker, R.S., and Barrentine, W.L.Comparative toxicity of several dinitroaniline herbicidesWeed Sci.26(1)72-75(1978) 2.Kili?, Z.S., Aydin, S., Bucurgat, ?.?., et al.In vitro genotoxicity assessment of dinitroaniline herbicides pendimethalin and trifluralinFood Chem. Toxicol.11390-98(2018) 3.Ahmad, M.I., Zafeer, M.F., Javed, M., et al.Pendimethalin-induced oxidative stress, DNA damage and activation of anti-inflammatory and apoptotic markers in male ratsSci. Rep.8(1)17139(2018)