PEG2000-DSPE is a PEG polymer containing DSPE and amine end groups that exhibits micelle-like properties [1]. PEG2000-DSPE has been widely used in the preparation of polymer micelles and liposomes to encapsulate doxorubicin, which can prolong the circulation time in the body and thereby increase the tumor uptake rate[2]. The introduction of PEG2000-DSPE will enhance the lateral repulsive force of the lipid bilayer surface through extensive hydration around the head group, not only affecting the particle size, but also influencing the lamellar structure of the vesicles [3]. PEG2000-DSPE has been widely used to modify the surface of nanoparticles or proteins, resisting the degradation by blood proteins and improving the pharmacokinetic behavior of nanocrystals[4].
References:
[1] Remsberg C M, Zhao Y, Takemoto J K, et al. Pharmacokinetic evaluation of a DSPE-PEG2000 micellar formulation of ridaforolimus in rat[J]. Pharmaceutics, 2012, 5(1): 81-93.
[2] Takayama R, Inoue Y, Murata I, et al. Characterization of nanoparticles using DSPE-PEG2000 and soluplus[J]. Colloids and Interfaces, 2020, 4(3): 28.
[3] Sriwongsitanont S, Ueno M. Effect of a PEG lipid (DSPE-PEG2000) and freeze-thawing process on phospholipid vesicle size and lamellarity[J]. Colloid and Polymer Science, 2004, 282(7): 753-760.
[4] Wang D, Wang Y, Zhao G, et al. Improving systemic circulation of paclitaxel nanocrystals by surface hybridization of DSPE-PEG2000[J]. Colloids and Surfaces B: Biointerfaces, 2019, 182: 110337.
PEG2000-DSPE是一种含有DSPE和胺端基的PEG聚合物，具有类似胶束的特性[1]。PEG2000-DSPE已被广泛用于制备聚合物胶束和脂质体以包封阿霉素，可延长体内循环时间，从而提高肿瘤摄取率[2]。PEG2000-DSPE的引入会通过头部基团周围的大量水化作用增强脂质双层的侧向排斥力，不仅影响粒径，还会影响囊泡的层状结构[3]。PEG2000-DSPE已被广泛用于修饰纳米颗粒或蛋白质的表面，抵抗血液蛋白的降解，并改善纳米晶体的药代动力学行为[4]。