GlpBio

PD-1/PD-L1 Inhibitor 3 (trifluoroacetate salt)

目录号: GC52425纯度: >95.00%同义词: Programmed Cell Death 1/Programmed Cell Death-Ligand 1 Inhibitor 3
A PD-1/PD-L1 interaction inhibitor
PD-1/PD-L1 Inhibitor 3 (trifluoroacetate salt)
规格价格库存数量操作
1 mg¥2,898.00现货
1
5 mg¥12,208.00现货
1
500 μg¥1,526.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    Cell Research
    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

PD-1/PD-L1 inhibitor 3 is a macrocyclic peptide inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1).1 It inhibits the PD-1/PD-L1 interaction in a time-resolved FRET (TR-FRET) assay (IC50 = 9 nM).

1.Miller, M.M., Mapelli, C., Allen, P., et al.Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions(2017)

产品文档 Product Documents

Purity:>95.00%Appearance:A solid

化学性质Chemical Properties

同义词
Programmed Cell Death 1/Programmed Cell Death-Ligand 1 Inhibitor 3
SMILES
O=C(N([C@H](C(N([C@H](C(N[C@H](C(N[C@@H](CSCC(N[C@H](C(N([C@H](C(N[C@H](C(N1[C@](CCC1)([H])C(N[C@H](C(N[C@H](C(N(CC(N[C@H](C(N[C@H](C(N2)=O)CO)=O)CC3=CNC4=CC=CC=C34)=O)C)=O)CC(C)C)=O)CC5=CN=CN5)=O)=O)CC(N)=O)=O)C)C)=O)CC6=CC=CC=C6)=O)C(NCC(N)=O)=O)=O)CCCNC(N)=N)=O)CCCC)C)=O)CCCC)C)[C@@H]2CC7=CNC8=CC=CC=C78.OC(C(F)(F)F)=O
分子式
C89H126N24O18S ? XCF3COOH
分子量
1852.2 g/mol
溶解性
30% ACN/H2O: soluble
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol