PCAF-IN-1 is a highly selective PCAF inhibitor. PCAF-IN-1 is a antitumor agents, which can be used in tumor research research[1].
PCAF-IN-1 (Compound 32) (10 μM, 72 hours; human tumor cell lines) exerts the most potent antitumor activities against human cancer cell lines[1].
Cell Cytotoxicity Assay[1]
| Cell Line: | Hepatocellular carcinoma (HePG-2), breast cancer (MCF-7), prostate cancer (PC3) and colorectal carcinoma (HCT-116). |
| Concentration: | 10 μM |
| Incubation Time: | 72 hours |
| Result: | Inhibited with IC50 values of 4.89, 6.18, 9.71 and 3.76 μM for HePG-2, MCF-7, PC3 and HCT-116, respectively. |
[1]. Turky A, et al. Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects. Bioorg Chem. 2020 Aug;101:104019.