Oxypertine is a neuroprotective agent. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia.
Oxypertine (0.44 nM-26 μM, 15 min) antagonizes dopamine and 5-HT induced contractions of the rat isolated vas deferens[1].
Oxypertine (8.8 nM, 15 min) reduces the contractions evoked by transmural stimulation of the vas deferens[1].
Oxypertine (10 and 35 mg/kg, i.p.) causes an obvious dose-related depletion in the levels of norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT) in various discrete regions of the rat brain[2].
Oxypertine (0.625-20 mg/kg, i.p.) inhibits stereotyped behaviour induced by both amphetamine and apomorphine in rats[3].