GlpBio

Orexin B amide (human) (trifluoroacetate salt)

目录号: GC49553纯度: >95.00%同义词: Hypocretin 2, OXB
A hypothalamic neuropeptide
Orexin B amide (human) (trifluoroacetate salt)
Cas No.: N/A
规格价格库存数量操作
500 µg¥4,902.00现货
1
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产品描述 Description

Orexin B amide is a hypothalamic neuropeptide that regulates feeding behavior, wakefulness, and behavior under situations of high motivational relevance.1 It is an agonist of orexin (OX) receptors with IC50 values of 420 and 36 nM for human recombinant OX1 and OX2 receptors, respectively, expressed in CHO cells.2 It induces transient increases in intracellular calcium in CHO cells stably expressing OX1 and OX2 (EC50s = 2,500 and 60 nM, respectively) and in primary rat ventral tegmental area (VTA) dopaminergic neurons.2,3 Orexin B amide stimulates arachidonic acid release from CHO cells expressing human recombinant OX1 (EC50 = 4.17 nM).4 It also stimulates food intake in freely feeding mice and goldfish when administered at intracerebroventricular doses of 30 nmol and 10 ng/g, respectively.2,5

1.Mahler, S.V., Moorman, D.E., Smith, R.J., et al.Motivational activation: A unifying hypothesis of orexin/hypocretin functionNat. Neurosci.17(10)1298-1303(2014) 2.Sakurai, T., Amemiya, A., Ishii, M., et al.Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviorCell92(4)573-585(1998) 3.Nakamura, T., Uramura, K., Nambu, T., et al.Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic systemBrain Res.873(1)181-187(2000) 4.Turunen, P.M., Ekholm, M.E., Somerharju, P., et al.Arachidonic acid release mediated by OX1 orexin receptorsBr. J. Pharmacol.159(1)212-221(2010) 5.Volkoff, H., Bjorklund, J.M., and Peter, R.E.Stimulation of feeding behavior and food consumption in the goldfish, Carassius auratus, by orexin-A and orexin-BBrain Res.846(2)204-209(1999)

产品文档 Product Documents

Purity:>95.00%Appearance:A lyophilized powder

化学性质Chemical Properties

CAS 号
N/A
同义词
Hypocretin 2, OXB
SMILES
NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(N)=O)NC(CNC([C@H](CO)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC(CNC([C@@H]1CCCN1C([C@@H]2CCCN2C(CNC([C@H](CO)NC([C@H](CCCNC(N)=N)N[H])=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)CC3=CN=CN3)=O)C)=O)C)=O)=O)=O)=O)=O)CCSC)=O.FC(F)(C(O)=O)F
分子式
C123H212N44O35S • XCF3COOH
分子量
2899.3 g/mol
溶解性
Water: 1 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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