GlpBio

Orexin A amide (bovine, human, mouse, rat) (trifluoroacetate salt)

目录号: GC52507纯度: >95.00%同义词: Hypocretin 1, OXA
A hypothalamic neuropeptide
Orexin A amide (bovine, human, mouse, rat) (trifluoroacetate salt)
规格价格库存数量操作
1 mg¥6,664.00现货
1
5 mg¥31,290.00现货
1
500 μg¥3,934.00现货
1
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文献被引

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    183(7):1867-1883 (2020)
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产品描述 Description

Orexin A is a 33 amino acid hypothalamic neuropeptide with a role in appetite regulation, wakefulness, locomotor activity, hypothalamic-pituitary-adrenal activity, and pain thresholds.1 Orexin signaling is activated by nutrient depletion, causing an increase in food intake by delaying the signals of satiety.2 It activates the orexin-1 and -2 receptors with equal affinity (EC50s = 0.09 and 0.06 μM, respectively).3

1.Rodgers, R.J., Ishii, Y., Halford, J.C.G., et al.Orexins and appetite regulationNeuropeptides36(5)303-325(2002) 2.Schwartz, M.W.Orexins and appetite: The big picture of energy homeostasis gets a little biggerNat. Med.4385-386(1998) 3.Lang, M., SÖll, R.M., DÜrrenberger, F., et al.Structure-activity studies of orexin A and orexin B at the human orexin 1 and orexin 2 receptors led to orexin 2 receptor selective and orexin 1 receptor preferring ligandsJ. Med. Chem.47(5)1153-1160(2004)

产品文档 Product Documents

Purity:>95.00%Appearance:A crystalline solid

化学性质Chemical Properties

同义词
Hypocretin 1, OXA
SMILES
NC([C@@H](NC([C@@]([H])(NC([C@@H](NC([C@@]([H])(NC(CNC([C@H](C)NC([C@H](C)NC([C@H](CC1=CN=CN1)NC([C@@H](NC(CNC([C@H](C)NC(CNC([C@H](CC2=CN=CN2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(C=C3)O)NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@@H]4N5)NC([C@@H](NC([C@H](CSSC[C@@H](C5=O)NC([C@H](CC(O)=O)NC([C@@H]6CCCN6C([C@@H](NC([C@@H]7CCCN7C(C8NC(CC8)=O)=O)=O)CC(C)C)=O)=O)=O)NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@H](NC4=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCCN)=O)[C@H](O)C)=O)=O)CO)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)=O)CCC(O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)=O)=O)CC(N)=O)=O)=O)=O)=O)=O)[C@@H](C)CC)=O)CC(C)C)=O)[C@H](O)C)=O)CC(C)C)=O.OC(C(F)(F)F)=O
分子式
C152H243N47O44S4 ? XCF3COOH
分子量
3561.1 g/mol
溶解性
DMSO: 3 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol