Olanexidine drochloride is a monobiguanide compound with bactericidal activity. Olanexidine probably binds to the cell membrane, destroys membrane integrity. Olanexidine drochloride is active against a wide range of bacteria, including Gram-positive and Gram-negative bacteria. Olanexidine exhibits the bactericidal concentration of 109 μg/mL for Gram-positive bacilli[1].
Olanexidine 显示出以下杀菌机制:(i) 与细菌表面分子相互作用，如脂多糖和脂磷壁酸；(ii) 破坏脂质体的细胞膜，这是人工细菌膜模型；(iii) 增强大肠杆菌的膜通透性；(iv) 破坏金黄色葡萄球菌的膜完整性，以及 (v) 在相对高浓度 (≥160 μg/ml) 下使蛋白质变性[1]。
[1]. Hagi A, et al. Bactericidal Effects and Mechanism of Action of Olanexidine Gluconate, a New Antiseptic. Antimicrob Agents Chemother. 2015 Aug;59(8):4551-9.