NSC 5844 is a bis-quinoline with diverse biological activities.1,2,3 It inhibits the growth of P. falciparum strains that are sensitive (D-6) and resistant (W-2) to chloroquine in vitro (IC50s = 17 and 27 nM, respectively) but lacks activity against P. berghei in vivo.1 NSC 5844 inhibits the growth of MDA-MB-468 and MCF-7 breast cancer cells with GI50 values of 7.35 and 14.80 μM, respectively.2 It also inhibits 24% of botulinum neurotoxin serotype A light chain (BoNT/A LC) metalloprotease activity at a concentration of 20 μM.3
1.Vennerstrom, J.L., Ellis, W.Y., Ager, A.L., Jr., et al.Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malariaJ. Med. Chem.35(11)2129-2134(1992) 2.Zhang, H., Solomon, V.R., Hu, C., et al.Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivativesBiomed. Pharmacother.62(2)65-69(2008) 3.Burnett, J.C., Schmidt, J.J., Stafford, R.G., et al.Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activityBiochem. Biophys. Res. Commun.310(1)84-93(2003)