GlpBio

Nogo-66 (1-40) (human, mouse, rat) (trifluoroacetate salt)

目录号: GC52382纯度: >95.00%同义词: NEP1-40, Nogo-40, Nogo-A Inhibitory Peptide, RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
A peptide fragment of Nogo-A
Nogo-66 (1-40) (human, mouse, rat) (trifluoroacetate salt)
规格价格库存数量操作
1 mg¥546.00现货
1
5 mg¥2,436.00现货
1
10 mg¥4,312.00现货
1
25 mg¥9,450.00现货
1
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产品描述 Description

Nogo-66 (1-40) is a peptide fragment of Nogo-A that corresponds to the extracellular domain, Nogo-66, which can induce neurite growth cone collapse in oligodendrocytes.1,2 It is also an antagonist of the Nogo-66 receptor (NgR).2 It inhibits binding of the NgR agonist AP-Nogo-66 to, and inhibits growth cone collapse induced by the NgR agonist GST-Nogo-66 in, embryonic day 12 (E12) chick dorsal root ganglia (DRG) explants.2 Nogo-66 (1-40) partially reverses axonal outgrowth inhibition induced by purified CNS myelin in E12 chick DRG explants (EC50 = 50 nM). It also induces regeneration of corticospinal tract fibers and improves locomotor function in a rat model of midthoracic spinal cord hemisection injury when administered intrathecally at a dose of 75 µg/kg per day.

1.Lim, M., Shi, J., Wei, Z., et al.Structural characterization of the human Nogo-A functional domains. Solution structure of Nogo-40, a Nogo-66 receptor antagonist enhancing injured spinal cord regenerationEur. J. Biochem.271(17)3512-3522(2004) 2.GrandPrÉ, T., Li, S., and Strittmatter, S.M.Nogo-66 receptor antagonist peptide promotes axonal regenerationNature417(6888)547-551(2002)

产品文档 Product Documents

Purity:>95.00%Appearance:A solid

化学性质Chemical Properties

同义词
NEP1-40, Nogo-40, Nogo-A Inhibitory Peptide, RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
SMILES
OC(C[C@H](NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@](NC([C@@H](NC([C@H](CCC(N)=O)NC([C@](NC([C@H](C(C)C)NC(CNC([C@H](CCCCN)NC([C@H](CC(C=C1)=CC=C1O)NC([C@](NC([C@H](CCCNC(N)=N)NC(C)=O)=O)([H])[C@H](CC)C)=O)=O)=O)=O)=O)([H])[C@H](CC)C)=O)=O)C)=O)([H])[C@H](CC)C)=O)=O)=O)=O)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC2=CNC=N2)C(N3CCC[C@H]3C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CC(C=C4)=CC=C4O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@](C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C=C5)=CC=C5O)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)([H])[C@H](CC)C)=O)C)=O)=O)=O)=O)=O)CC(C)C)=O)=O)C)=O)=O)CC6=CC=CC=C6)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式
C206H324N56O65 ? CF3COOH
分子量
4739.1 g/mol
溶解性
Water: 1mg/mL
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol