The NLRP3 protein acts as a sensor in the NLRP3 inflammasome, which is activated in response to membrane defects. It forms a complex with CASP1 and PYCARD/ASC, promotes the release of IL1B, IL18 and GSDMD, and induces pyroptosis. NLRP3 Protein, Human (His)
NLRP3 蛋白作为 NLRP3 炎症小体的传感器组件，协调炎症小体的激活，以响应损害膜完整性的各种刺激，导致炎症细胞因子 IL1B 和 IL18 的分泌以及细胞焦亡。在存在影响膜完整性的病原体或损伤相关信号的情况下，NLRP3 启动炎性体复合物的组装，该复合物包括 NLRP3、CASP1 和 PYCARD/ASC。这导致 caspase-1 前体的募集和激活，随后裂解并激活 IL1B、IL18 和 Gasdermin-D (GSDMD)，促进细胞因子释放和焦亡细胞死亡。激活刺激包括细胞外ATP、尼日利亚菌素、活性氧、晶体、β-淀粉样蛋白纤维和各种颗粒或纳米颗粒。有趣的是，NLRP3 还在调节辅助性 T 2 (Th2) 细胞的分化中发挥作用，有助于 Th2 细胞依赖性过程，例如哮喘和肿瘤生长。在 Th2 分化过程中，NLRP3 参与 IRF4 与 IL4 启动子的最佳结合以及 IRF4 依赖性 IL4 转录，突出了其除炎症体激活之外的多方面功能。 is the recombinant human-derived NLRP3, expressed by E. coli, with C-6*His labeled tag.
NLRP3 Protein, Human (His)
目录号: GP27283纯度: >98%
NLRP3 蛋白充当 NLRP3 炎症小体中的传感器，该传感器响应膜缺陷而被激活。它与CASP1和PYCARD/ASC形成复合物，促进IL1B、IL18和GSDMD的释放，并诱导细胞焦亡。NLRP3 蛋白, Human (His) 是重组的 NLRP3 蛋白，由 E. coli 表达，带有 C-6*His 标签。
| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 20ug | ¥1,800.00 | 现货 | 1 | |
| 50ug | ¥3,600.00 | 现货 | 1 | |
| 100ug | ¥5,760.00 | 现货 | 1 |
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Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
产品描述 Description
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Purity:>98%
Product Data
Purity
Greater than 90% as determined by reducing SDS-PAGE.
Source
E. coli
Physical Appearance
Lyophilized powder
Shipping Condition
Room temperature in continental US; may vary elsewhere.
Synonyms
Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; Cold-induced autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1; NLRP3; NALP3; PYPAF1; CIAS1
Apparent Molecular Weight
Approximately 72 kDa Da
Stability
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Formulation
Lyophilized from a 0.22 μm filtered solution of PBS, 6% Trehalose, pH 7.4 or 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0. Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips