GlpBio

Nicotine

目录号: GC14043纯度: >95.00%同义词: (+/-)-尼古丁,(±)-Nicotine

An agonist at neuronal nicotinic acetylcholine receptors

Nicotine
Cas No.: 22083-74-5
规格价格库存数量操作
100mg¥1,136.00现货
1
250mg¥2,703.00现货
1
500mg¥3,978.00现货
1
10mM (in 1mL DMSO)¥374.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    31, 1291–1307 (2021)

产品描述 Description

(±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs; Kis = 481 and 11.1 nM for α3β4 and α4β2 subtypes, respectively) and possesses addictive and teratogenic properties.1 (−)-(S)-Nicotine is significantly more active at binding nAChRs compared to the (+)-(R) antipode, thus nicotine is typically synthesized as (−)-(S)-nicotine with only 0.2-1% of the (+)-(R) isomer present.2
References
1. Zaveri, N., Jiang, F., Olsen, C., et al. Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J. Med. Chem. 53(22), 8187-8191 (2010).
2. Clayton, P., Lu, A., and Bishop, L. The pyrolysis of (−)-(S)-nicotine: Racemization and decomposition. Chirality 22(4), 442-446 (2010).

产品文档 Product Documents

Purity:>95.00%

相关生物学数据Related Biological Data

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化学性质Chemical Properties

CAS 号
22083-74-5
同义词
(+/-)-尼古丁,(±)-Nicotine
化学名
(R)-3-(1-methylpyrrolidin-2-yl)pyridine
SMILES
CN1[C@@H](C2=CC=CN=C2)CCC1
分子式
C10H14N2
分子量
162.23 g/mol
溶解性
30mg/mL in DMSO, 50mg/mL in DMF, 50mg/mL in Ethanol
保存条件
Store at -20°C,protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol