Neuromedin U-23 (rat) (trifluoroacetate salt) is a 23-amino acid brain-gut peptide found in the central nervous system and peripheral tissues[1]. Neuromedin U-23 can contract smooth muscle, regulate blood pressure, and participate in pain perception, appetite, bone growth, and hormone release[2, 3]. Neuromedin U-23 has shown anxiolytic effects in animal elevation and maze tests and participates in the regulation of β-adrenergic and cholinergic nervous systems[4]. Long-term administration of Neuromedin U-23 can reduce body weight, decrease food intake, and increase core body temperature in mice[5, 6].
References:
[1] Szekeres P G, Muir A I, Spinage L D, et al. Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3[J]. Journal of Biological Chemistry, 2000, 275(27): 20247-20250.
[2] De Prins A, Allaoui W, Medrano Moya M, et al. Effects of neuromedin U-8 on stress responsiveness and hypothalamus-pituitary-adrenal axis activity in male C57BL/6J mice. IF (2019) 3,684[J].
[3] Yu X H, Cao C Q, Mennicken F, et al. Pro-nociceptive effects of neuromedin U in rat[J]. Neuroscience, 2003, 120(2): 467-474.
[4] Tanaka M, Telegdy G. Neurotransmissions of antidepressant-like effects of neuromedin U-23 in mice[J]. Behavioural brain research, 2014, 259: 196-199.
[5] Peier A, Kosinski J, Cox-York K, et al. The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2)[J]. Endocrinology, 2009, 150(7): 3101-3109.
[6] Masuda Y, Kumano S, Noguchi J, et al. PEGylated neuromedin U-8 shows long-lasting anorectic activity and anti-obesity effect in mice by peripheral administration[J]. Peptides, 2017, 94: 99-105.
Neuromedin U-23 (rat) (trifluoroacetate salt)是一种含23个氨基酸的脑肠肽，存在于中枢神经系统和外周组织中[1]。Neuromedin U-23能够收缩平滑肌、调节血压，并参与疼痛感知、食欲、骨骼生长和激素释放[2, 3]。Neuromedin U-23在动物升高加迷宫试验中表现出抗焦虑效果，并参与β肾上腺素能和胆碱能神经系统调节[4]。Neuromedin U-23长期给药能够减轻小鼠体重，减少食物摄入，并提高小鼠的核心体温[5, 6]。