Nasunin, an antioxidant anthocyanin, possesses antiangiogenic activity[1].
Nasunin at higher 10 µM suppresses microvessel outgrowth in an ex vivo angiogenesis assay using a rat aortic ring[1].
Nasunin suppresses HUVEC proliferation in a dose-dependent manner (50-200 µM)[1].
Nasunin diminishes LPS-induced nuclear factor-κB (NF-κB) activation by suppressing thedegradation of inhibitor of κB-α and nuclear translocation of p65 subunit of NF-κB. Nasunin also attenuates the phosphorylation of Akt and p38, signaling molecules involved in pro-inflammatory mediator production[1].
[1]. Kiminori Matsubara, et al. Antiangiogenic activity of nasunin, an antioxidant anthocyanin, in eggplant peels. J Agric Food Chem. 2005 Aug 10;53(16):6272-5.
[2]. Wataru Komatsu, et al. Nasunin inhibits the lipopolysaccharide-induced pro-inflammatory mediator production in RAW264 mouse macrophages by suppressing ROS-mediated activation of PI3 K/Akt/NF-κB and p38 signaling pathways. Biosci Biotechnol Biochem. 2017 O