Naftazone is a naphthoquinone derivative, it can be used for the research of venous insufciency. Naftazone protects blood vessels, increases venous tonicity and capillary resistance, and improves lymphatic and venous circulation.
Naftazone (0.5-50 μM; 1 h) reduces glutamate release from mouse cerebellum synaptosomes[1].
Naftazone (10 and 100 mg/kg; p.o. once per day for 15 days) affects glutamate content in cerebro spinal fluid[1].
Naftazone (50 mg/kg; i.p. once per day for 5 days) affects platelet function in rats[2].
References:
[1]. Mattei C, et al. Naftazone reduces glutamate cerebro spinal fluid levels in rats and glutamate release from mouse cerebellum synaptosomes. Neurosci Lett. 1999 Aug 27;271(3):183-6.
[2]. McGregor L, et al. Effect of naftazone on in vivo platelet function in the rat. Platelets. 1999;10(1):66-70.