N6-Benzyladenosine-5'-O-triphosphate (sodium salt)

N⁶-Benzyladenosine-5'-O-triphosphate is an N-phenyl-substituted derivative of ATP and a ligand used for bump and hole, a technique to study single protein isoforms when familial homology would interfere with other isoform-selective approaches.¹ It is 7-fold selective for inhibiting the ATP binding and ATPase activity of myosin light chain (MLC) containing a tyrosine-to-glycine substitution at position 61 (MLC^Y61G) over the wild-type enzyme. N⁶-Benzyladenosine-5'-O-triphosphate has been used to develop a technique to identify substrates of the programmed cell death-suppressor kinase AvrPto-dependent Pto-interacting protein 3 (Adi3) in tomato plants.²