GLPBio

N-Sterol

目录号: GC92413纯度: >95.00%
N-Sterol is a sterol lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.
N-Sterol
规格价格库存数量操作
1mg¥554.00现货
1
5mg¥2,218.00现货
1
10mg¥3,326.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

N-Sterol is a sterol lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing N-sterol and encapsulating mRNA encoding a reporter are uptaken via clathrin-coated pits, caveolin-mediated endocytosis, micropinocytosis, or phagocytosis with different frequencies in a lipid composition-dependent manner in J774A.1 macrophages. The same LNPs demonstrate improved endosomal escape in J774A.1 macrophages over LNPs containing SM-102 . In vivo, N-sterol LNPs encapsulating an mRNA reporter selectively accumulate in mouse spleens.

产品文档 Product Documents

Purity:>95.00%

化学性质Chemical Properties

化学名
(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (E)-3-((2-methoxyethyl)(methyl)amino)acrylate
SMILES
O=C(O[C@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@]([C@H](C)CCCC(C)C)([H])CC[C@@]4([H])[C@]3([H])CC=C2C1)/C=C/N(C)CCOC
分子式
C34H57NO3
分子量
527.834 g/mol
溶解性
Ethanol: Slightly soluble: 0.1-1 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol