N-octanoyl-L-Homoserine lactone is a bacterial signaling molecule [1]. N-octanoyl-L-Homoserine lactone binds to and activates the LuxR family transcription factors in bacteria, initiates the expression of downstream quorum sensing-related genes, and regulates group behaviors such as biofilm formation, virulence factor production, and antibiotic resistance [2-3]. N-octanoyl-L-Homoserine lactone is used in the study of bacterial communication mechanisms and the development of anti-infective drugs [4].
References:
[1]. Williams C C, Ajibade G A, Yilwa V M, et al. Signaling Molecules in Pseudomonas aeruginosa Response to Antibiotics at Sub-Inhibitory Concentrations[J]. Asian Journal of Biotechnology and Bioresource Technology, 2024, 10(4): 60-71.
[2]. Khider M, Hansen H, Hjerde E, et al. Exploring the transcriptome of luxI− and ΔainS mutants and the impact of N-3-oxo-hexanoyl-L-and N-3-hydroxy-decanoyl-L-homoserine lactones on biofilm formation in Aliivibrio salmonicida[J]. PeerJ, 2019, 7: e6845.
[3]. Whitehead N A, Barnard A M L, Slater H, et al. Quorum-sensing in Gram-negative bacteria[J]. FEMS microbiology reviews, 2001, 25(4): 365-404.
[4]. Sarveswari H B, Solomon A P. Profile of the intervention potential of the phylum actinobacteria toward quorum sensing and other microbial virulence strategies[J]. Frontiers in Microbiology, 2019, 10: 2073.
N-octanoyl-L-Homoserine lactone是一种细菌信号分子 [1]。N-octanoyl-L-Homoserine lactone能结合并激活细菌中的LuxR家族转录因子，启动下游群体感应相关基因的表达，并调节生物膜形成、毒力因子产生和抗生素耐药性等群体行为 [2-3]。N-octanoyl-L-Homoserine lactone用于研究细菌通讯机制和抗感染药物的研发 [4]。