N-Nitrosodimethylamine-d6 is intended for use as an internal standard for the quantification of N-nitrosodimethylamine by GC- or LC-MS. N-Nitrosodimethylamine is a nitrosamine.1,2,3 It has been found in tobacco smoke, pesticides, alcoholic beverages, and several food products, including cured meats.1,2 Nitrosodimethylamine (50 mg/L in the drinking water) induces tumors in mice and inhalation at 0.2 mg/m3 induces tumors in rats.1
1.IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans: Some N-nitroso compounds(1978) 2.Park, J.-e., Seo, J.-e., Lee, J.-y., et al.Distribution of seven N-nitrosamines in foodToxicol. Res.31(3)279-288(2015) 3.Report on carcinogens, fourteenth edition(2016)