N-Nitroso-N-methylaniline is an N-nitrosamine.1 It induces the formation of esophageal, pharyngeal, and tongue tumors in rats when administered at a concentration of 200 mg/L in the drinking water or 15 mg/ml via oral gavage.2 N-Nitroso-N-methylaniline is toxic to rats with LD50 values of 336 and 225 mg/kg for male and female rats, respectively. It reduces survival of hamsters but only induces a low incidence of tumors in this species when administered at a dose of 5 mg/week for a total dose of 1.8 mmol.1
1.Lijinsky, W., and Kovatch, R.M.Comparative carcinogenesis by nitrosomethylalkylamines in Syrian hamstersCancer Res.48(23)6648-6652(1988) 2.Goodall, C.M., Lijinsky, W., Tomatis, L., et al.Toxicity and oncogenicity of nitrosomethylaniline and nitrosomethylcyclohexylamineToxicol. Appl. Pharmacol.17(2)426-432(1970)