Calcium ionophore II is a neutral calcium ionophore.1 It is selective for calcium over strontium, manganese, cobalt, nickel, zinc, lanthanum, sodium, potassium, and magnesium. Calcium ionophore II binds to calcium in a 1:3 (ligand:ion) ratio and induces calcium transport across artificial membranes and into rat liver mitochondria.2 It induces sea urchin egg activation when used at a concentration of 100 pM. Calcium ionophore II has been used in the preparation of calcium-selective electrodes.3
1.Wang, E., Erdahl, W.L., Hamidinia, S.A., et al.Transport properties of the calcium ionophore ETH-129Biophys J.81(6)3275-3284(2001) 2.Prestipino, G., Falugi, C., Falchetto, R., et al.The ionophore ETH 129 as Ca2+ translocator in artificial and natural membranesAnal. Biochem.210(1)119-122(1993) 3.Park, S., Maier, C.S., and Koley, D.Anodic stripping voltammetry on a carbon-based ion-selective electrodeElectrochim. Acta390138855(2021)