N-Methylnuciferine is an aporphine alkaloid that has been found in A. cherimola and has diverse biological activities.[1],[2] It scavenges DPPH radicals (IC50 = 711.76 µg/ml) and inhibits α-glucosidase and α-amylase (IC50s = 2,627.78 and 1,818.18 µg/ml, respectively) in cell-free assays.[1] N-Methylnuciferine (20 µM) reduces LPS-induced nitric oxide (NO) production in BV-2 microglia.[2]
References:
[1].Galarce-Bustos, O., Obregón, C., Vallejos-Almirall, A., et al.Application of effect-directed analysis using TLC-bioautography for rapid isolation and identification of antidiabetic compounds from the leaves of Annona cherimola MillPhytochem. Anal.34(8)970-983(2023).
[2].Chen, S., Guo, W., Qi, X., et al.Natural alkaloids from lotus plumule ameliorate lipopolysaccharide-induced depression-like behavior: Integrating network pharmacology and molecular mechanism evaluationFood Funct.10(9)6062-6073(2019).