N-Methyl-4-pyridone-5-carboxamide is a metabolite of nicotinic acid and a uremic toxin.1,2 Plasma levels of N-methyl-4-pyridone-5-carboxamide are increased and positively correlated with serum levels of malondialdehyde (MDA) in patients with chronic kidney disease (CKD).2
1.Chang, M.L.W., and Johnson, B.C.N-Methyl-4-pyridone-5-carboxamide as a metabolite of nicotinic acid in man and monkeyJ. Biol. Chem.2362096-2098(1961) 2.Rutkowski, P., S?ominska, E.M., Szo?kiewicz, M., et al.Relationship between uremic toxins and oxidative stress in patients with chronic renal failureScand. J. Urol. Nephrol.41(3)243-248(2007)