N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys (fNLFNYK) is a synthetic chemotactic peptide.[1],[2] It binds to the formyl peptide receptor (FPR; Kd = 2.2 nM).[1] fNLFNYK has been conjugated to various fluorophores to monitor FPR internalization.[3]
References:
[1].Niedel, J.E.The formyl peptide chemotactic receptor: Cellular processing of peptide and receptorReceptor-Mediated Endocytosis. Receptors and Recognition15273-299(1983).
[2].Boulay, F., Tardif, M., Brouchon, L., et al.Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNABiochem. Biophys. Res. Commun.168(3)1103-1109(1990).
[3].Yan, P., Nanamori, M., Sun, M., et al.The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand bindingJ. Immunol.177(10)7050-7058(2006).