GlpBio

N-butyl Lithocholic Acid

目录号: GC92013纯度: >98.00%同义词: N-butyl LCA; N-butyl Lithocholate
N-butyl Lithocholic Acid是次级胆汁酸石胆酸的衍生物。
N-butyl Lithocholic Acid
Cas No.: 135013-42-2
规格价格库存数量操作
1 mg¥490.00现货
1
5 mg¥1,596.00现货
1
10 mg¥2,940.00现货
1
25 mg¥6,132.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6734) (2025)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

N-butyl Lithocholic acid is a derivative of the secondary bile acid lithocholic acid.1 Lipid nanoparticles (LNPs) containing N-butyl lithocholic acid and encapsulating an mRNA vaccine expressing influenza hemagglutinin exhibit less heart, spleen, and liver toxicity than LNPs containing cholesterol in mice.

References:
[1]. Bae, S.-H., Yoo, S., Lee, J., et al.A lipid nanoparticle platform incorporating trehalose glycolipid for exceptional mRNA vaccine safetyBioact. Mater.38486-498(2024).

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
135013-42-2
同义词
N-butyl LCA; N-butyl Lithocholate
化学名
(3α,5β)-3-hydroxy-cholan-24-oic acid, butyl ester
SMILES
C[C@H](CCC(OCCCC)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
分子式
C28H48O3
分子量
432.7 g/mol
溶解性
DMSO: Slightly soluble: 0.1-1 mg/ml,Ethanol: Sparingly soluble: 1-10 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol